Birth Control for Men?

Sounds like an oxymoron, right?  But it’s true.

Now it’s the man’s turn to assume some responsibility in the contraceptive arena!  No longer is it just a man’s choice between using condoms  or getting a vasectomy.  Amazing new options are on the horizon!  Researchers are investigating various forms, targeted solely towards men, which are showing very promising results.  These options range from a long-acting injectable gel to a quick-acting male pill that could potentially markedly reduce the transmission of HIV.

According to a recent survey conducted by the U.S. Government’s Center for Disease Control (CDC), more than 80 percent of heterosexual women have used birth control pills at some point in their lives to prevent pregnancy.    Birth control pills became available to women in the 1960’s and represent the most common contraceptive used in the United States today.  Interestingly, global demand for male birth control appears increasingly popular, with a 2005 German survey revealing that 60 percent of men in Spain, Germany, Brazil and Mexico are willing to use a male contraceptive.

What is this new injection procedure?

It’s called Vasalgel and involves an injection into a man’s genitals which inhibits sperm motility.  It’s a new form of contraception known as, RISUG, reversible inhibition of sperm under guidance (1).  Yes, many men may become queasy just imagining a needle being injected into these tender areas.  After receiving a local anesthetic, a small amount of polymer gel is inserted into the vas deferens of each testicle.   The vas deferens is the conduit which transports sperm from the testicle to the penis.  The procedure apparently takes less than 15 minutes, works by destroying the sperm, lasts up to 10 or more years and is more easily reversible than a vasectomy!

When and if the man decides to return his sperm back to speedy and motile swimmers, another shot is given.  Within 2-3 months, active, functional sperm are functioning again.

These studies have been ongoing for the past 25 years and found to be safe in both humans and animals.  Researchers are optimistic that the procedure will become available in the U.S. by 2015, with clinical trials beginning this year.  At present, trials are only being conducted in India.

What about the new male birth control pill

In Papua Island, Indonesia, tribesmen have discovered a shrub called “Gandarusa” that acts like a birth control pill for men.  Per one tribesman, “If you chew the leaves often enough, your wife won’t get pregnant.”  The potential benefits derived from this shrub are undergoing close evaluation and appear to work by slowing down the activity of certain enzymes in the sperm that allow them to penetrate a woman’s egg.  For fertilization to occur, a sperm must enter the egg.  According to Sugiri Syarief, the head of Indonesia’s state-run National Family Planning Coordination Board, multiple animal and human trials have been conducted since the 1990’s and the plant’s effective compound was patented in 2007.  Researchers have tested the pill on two different groups of male volunteers, the first 36 men, and later with 120 men.  Trials involving more than 350 men are presently being done to verify that the sperm remain healthy yet are incapable of this critical penetration process in fertilization.

What else is looming on the horizon? 

Possibly another type of male birth control pill may become available.  Discovered by accident while studying male infertility patients, a group of Scottish scientists recently found a key gene essential for sperm development.   Per Dr. Lee Smith at the University of Edinburgh in Scotland, if scientists are able to regulate the Katna1 gene in the testes, they could prevent sperm from maturing completely, making them ineffective without changing hormone levels (2).

So why hasn’t the male birth control pill become available in the United States?

Profit, or lack thereof, is the apparent culprit!   Per Elaine Lissner, director of the non-profit Male Contraception Information Project in San Francisco, the impasse to male birth control pills has been the lack of profitability for the pharmaceutical giants.  “It’s a nightmare from the ‘for-profit’ standpoint.  We have to accept that the needs of for-profit entities and the needs of the public don’t always perfectly match.”

Definitely makes one wonder – what are pharmaceutical companies actually pouring their financial resources into?  Another drug for erectile dysfunction which makes a hearty return on investment or a male birth control pill which yields little return but carries huge global population impact?  Well, time will tell but I’m thinking the former!

What do you think?  Please share your comments!

Citations:

1. http://www.globalpost.com/dispatch/news/asia-pacific/indonesia/110224/indonesia-birth-control-pill-papua-men

2. http://www.globalpost.com/dispatch/news/health/120525/sperm-gene-discovery-could-lead-to-male-birth-control-pill

 

Lighting the way…

Dr. Diana

Dr. Diana
 

Where is YOUR “Red Room”?

Where is your “red room”?

If you could fantasize about having a hot, sexy encounter anywhere in the world, where would it be?

My last blog highlighted the nation’s infatuation with the female erotic novel, Fifty Shades of Grey. In this romantic novel, the virginal female protagonist, Anastasia Grey, engages in sexual encounters with the gorgeous, multifaceted male hero, Christian Grey. In his house, Christian and Anastasia explore the boundaries of their sexual relationship in a small, ….. coined, “ the red room”.

And while we might fantasize about having a “red room” built into our own homes, where else would you dream about fueling the fires of desire?

Can you guess what the #1 place was for women? For men?

An intriguing study, recently done by the Durex Corporation, posed this exact question to 1,000 American adults, ages 18 and older, between March 16- March 23, 2012. Interestingly, the Durex Corporation manufactures condoms and conducts multiple titillating trials on sexual health every year. In this particular study, called the InSync Study, the top tryst sites to “get it on” were surveyed.

What was the number one place for women? The Eifel Tower! Yes, the highest percentage of women interviewed, 33 percent, fantasized about a sexual rendezvous at this romantic icon nestled in the heart of Paris.

For men? Amazingly, the White House! Thirty-one percent of the men polled chose the site associated with extreme power — and where some of our past presidents have even engaged in romantic interludes.

How can we explain these results? Interestingly, quite easily. Women, in general, love romance. Just imagine hearing the sweet sound of French music playing in the background, the smell of….in the air, the slight breeze brushing across your cheeks, the taste of his gentle kiss as you both gaze upon the river Seine. Wow, even I was being carried away with that one!!

For men, sexual fantasy is more about power. The White House is the ultimate symbol of authority, respect and command of our nation.

Why do we fantasize about having sex in mysterious places? Because too many of our sex lives are in a “rut” and need some major resuscitation! In fact, half of Americans interviewed in this same study were dissatisfied with their bedroom escapades. Of respondents interviewed, 37% admitted that their intimate time ends far too quickly. On the flip side, 14% revealed that sex lasts longer than they would like.

Some good news…

Even before Fifty Shades of Grey hit the shelves and heated women’s sexual desires across the country, Americans were already becoming more adventurous in the bedroom. According to another study by Durex, called the Durex Global Sexual Wellbeing Survey , which interviewed over 29,000 adults, aged 18 and older, between Sept 6 and October 3, 2011, American couples are actually trying new things to spice it up and get more “in sync” in the bedroom. These included using new types of lubricants (53%), adult toys and aids (39%), and rings (11%).

Can’t fly to Paris or Washington, D.C.? Or build your own red room?

Well, here are some places to heat things up in your home.

Top 5 places to have sex – around the house!
1. In the shower. Lathering each other with body wash can get you both incredibly squeaky clean as well as get you feeling sensuous.
2. In the bath tub. If the shower sounds a bit too acrobatic, run a bubble bath, soak in the wonderful…. And give each other a foot massage. Then feel free to massage other places.
3. In the kitchen. Remember the scene from “The Mailman Always Rings Twice”? Maybe while cooking up a delicious meal with your honey, sipping a glass of wine, slowly stirring the garlic simmering in the olive oil… you get the drift!
4. In the backyard. Just make sure that there are some trees or other shrubs to obstruct your neighbor’s view!
5. In the laundry room… think spin cycle.

Citations:
1) InSync Study, Durex Corporation, http://www.prnewswire.com/news-releases/durex-survey-reveals-what-americans-really-want-in-the-bedroom-149464045.html
2) Durex Global Sexual Wellbeing Survey: http://www.durex.com/en-ca/sexualwellbeingsurvey.

One Step Closer to a “Female Viagra”?

We’ve all seen the commercials for the little blue pill, Viagra. Men jumping for joy while the song , “We are the Champions”, by Queen, is blasting in the background. Ever wonder why the little blue pill that has worked wonders for male sexual dysfunction never made it into a little “pink” pill?

Well, new research led by a team of researchers at Pfizer’s labs in England, using a novel prototype drug may pave the way for discovering more about the mechanisms underlying female sexual arousal and developing a “female Viagra”. (1),

It is estimated that approximately 40% of women experience some type of sexual disorder, with desire and arousal being the most common (2,3). At present there is not a single US FDA approved medication for treatment of sexual problems in women. When Pfizer initially marketed Viagra for men, there were high hopes that Viagra, sildenafil citrate, would work as effectively for women and represent the “Holy Grail” that many pharmaceutical companies were vying to find.

The Advent of the “Blue Pill”

Viagra was initially developed by British scientists and brought to market by Pfizer, becoming available in 1998. Since this time, sildenafil has been the primary treatment for erectile dysfunction in men. Viagra works by increasing blood flow, or vasocongestion, in the erectile tissue located in the penis. For those biochemists out there, the mechanism of action involves the protection of cyclic guanosine monophosphate (cGMP) from being metabolized by a certain enzyme, phosphodiesterase type 5, leading to smooth muscle relaxation and increased inflow of blood into the spongy tissue of the penis, causing an erection (4).

What did studies in women taking Viagra find?

Definitely not the same results as in men! One large study involved premenopausal and postmenopausal women with female sexual arousal disorder comparing 10-100 mg sildenafil with matching placebo. Unfortunately, there was no perceived difference in improvement of sexual response in the women in the Viagra compared to placebo (5). Other studies also confirmed these findings.

So how are we a step closer to a “female Viagra”?
A research group led by Chris Wayman at the Pfizer lab found that electrically stimulating the pelvic nerve increases blood flow to the genitalia and that by using a prototype drug ( UK-414, 498) this effect was enhanced. The drug which was tested on rabbits and found increased blood flow specifically to the genitalia. The key component is that arousal was initially stimulated in the female rabbits and then the drug was administered. “The drug would not create arousal out of nowhere, however, would boost blood flow when accompanied by desire and sexual stimulation”, said Wayman.

According to Sheryl Kingsberg at Case Medical Center in Cleveland, this new discovery will help only a minority of women who have diagnosable arousal disorders, approximately 5% of women (6). “This is the closest thing out there to Viagra for women, but the problem is that a Viagra-like effect will not solve the majority of sexual dysfunction cases in women. In contrast to men in whom erections have played a huge role in sexual health, for women arousal is not the key problem, desire is.”

Though the prototype itself is unlikely to become a drug according to Wayman, “Testing the drug has helped to defog the mystery behind Female Sexual Arousal Disorder.”So we are left with the million dollar question of how to increase desire in women.

As we know female sexual response is complex and can’t be flipped on like a light switch. It’s more like a complex control panel.

Presently, researchers are investigating specific medications which work “above the belt” in women, targeting areas in the brain responsible for desire…because for women, the main sexual organ is the brain!

In the meantime, start doing your own research.

What make you feel more desire?
What makes you feel more desirable?

I believe that “you first need to feel desirable — to then have desire- “

Citations:
1. Wayman, CP. et al. UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit. British Journal of Pharmacology. 2010; May: 160 (1): 51-59.

2. Laumann, EO. et al. Sexual Dysfunction in the United States: Prevalence and Predictors. JAMA, 1999; 281 (6): 537 -544.

3. Laumann, EO et al. A population- based survey of sexual activity, sexual problems and associated help-seeking behavior patterns in mature adults in the United States of America. Int.J. Impot. Res. 2009; May-June: 21(3): 171-178.
4. Webb, DJ et al. Sildenafil citrate and blood-pressure lowering drugs : results of drug interaction studies with an organic nitrate and a calcium antagonist. Am. J. Cardiol, 1999; 83: (5A): 21C – 28C.

5. Basson, R. et al. Efficacy and safety of sildenafil citrate in women associated with female sexual arousal disorder. Journal of Women’s Health and Gender-Based Medicine. 2002;11:367-377.

6. Are We a Step Closer to a Viagra for Women? http://abcnews.go.com/Health/Wellness/viagra-women-female-sexual-dysfunction-spotlight.

Craving Sex At Mid-Cycle?

Ever wonder why some days of the month you feel extra amorous towards your partner, while other days you might rather just take a bath by yourself? Well, mother nature is playing a key role in this monthly orchestration of hormonal overtures.
Read More

Why Doesn’t He Want to Cuddle After Sex?

Ever wonder why he just doesn’t seem to want to cuddle after sex?

You may want to talk, savor in the afterglow of intimacy and share your innermost feelings…and he goes to sleep! Well, there actually is a physiological reason for this seemingly perplexing phenomenon.

Remember in a previous e-mail, I mentioned the importance of oxytocin as the “bonding hormone” and discussed its remarkable protection of heart disease – by giving 8 hugs a day to your partner, friend or family member, you will be reducing your and their risk of stroke and heart attack!
Read More

How often do we think about sex?

freeimages.co.uk workplace images

Let’s take a quiz!

1.    On average, how often do you think men think about sex in a day?

a) once a day
b) 3 times a day
c) 30-35 times a day
d) more than 35 times a day

 

 

 

And now, for the ladies…

2.    How often do you think women think about sex in a day?

a) once a day
b) 3 times a day
c) 30-35 times a day
d) more than 35 times a day

The answers might surprise you…


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